SYNTHETIC ANTIMICROBIAL PEPTIDE IDENTIFIED USING ARTIFICIAL INTELLIGENCE INHIBIT GROWTH OF ANTIBIOTIC RESISTANT PSEUDOMONAS AERUGINOSA IN VITRO

Basant; Pallavi Shah; Andleeb ArifRupesh GangwarSabapathi NagappanSonal SaxenaSameer Shrivastava

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SYNTHETIC ANTIMICROBIAL PEPTIDE IDENTIFIED USING ARTIFICIAL INTELLIGENCE INHIBIT GROWTH OF ANTIBIOTIC RESISTANT PSEUDOMONAS AERUGINOSA IN VITRO

机译：SYNTHETIC ANTIMICROBIAL PEPTIDE IDENTIFIED USING ARTIFICIAL INTELLIGENCE INHIBIT GROWTH OF ANTIBIOTIC RESISTANT PSEUDOMONAS AERUGINOSA IN VITRO

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Owing to gradual rise in multidrug-resistant (MDR) pathogens, antimicrobial resistance has become a major challenge and demands discovery of new antimicrobials to tackle this global health threat. To this end, we report a synthetic cationic peptide of 17 amino acids identified in tail protein of Pseudomonas phage with the help of Artificial intelligence (AI). The peptide was chemically synthesized and tested for its activity against Pseudomonas aeruginosa, which were isolated from clinical mastitic milk samples and initially characterized for resistance to antibiotics. The minimum inhibitory concentration (MIC) of synthesized peptide against standard strain of Pseudomonas aeruginosa (ATCC 27853) was found to be 60 μM. Then the peptide at MIC, 2×MIC,and 4×MIC concentration were tested against clinical isolates resistant to different antibiotics and it was observed that 75% isolates showed >90% inhibition at 4×MIC. This peptide showed <10% hemotoxicity and was stable in presence of physiological concentrations of different salts.

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《Indian journal of comparative microbiology, immunology and infectious dieases》 |2022年第2期|99-107|共9页
作者
Basant; Pallavi Shah; Andleeb ArifRupesh GangwarSabapathi NagappanSonal SaxenaSameer Shrivastava;
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作者单位

Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar-243122, Bareilly, Uttar Pradesh, India;

Post Graduate Trainee, Khandelwal College of Management, Science and Technology, Bareilly, Uttar Pradesh, India;

Facility for Research and Training on Bioassays and Biosensors, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar-243122, Bareilly, Uttar Pradesh, India;

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原文格式 PDF
正文语种英语
中图分类微生物学;
关键词
Synthetic peptide; Pseudomonas aeruginosa; Antimicrobial resistance; Artificial intelligence;

SYNTHETIC ANTIMICROBIAL PEPTIDE IDENTIFIED USING ARTIFICIAL INTELLIGENCE INHIBIT GROWTH OF ANTIBIOTIC RESISTANT PSEUDOMONAS AERUGINOSA IN VITRO

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