From Screening to Scale-Up: The DoE-Based Optimization of Electrochemical Reduction of L-Cystine at Metal Cathodes

Seidler Johannes; Bernhard Rebecca; Haufe StefanNeff CarolineGaertner TobiasWaldvogel Siegfried R.

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From Screening to Scale-Up: The DoE-Based Optimization of Electrochemical Reduction of L-Cystine at Metal Cathodes

机译：From Screening to Scale-Up: The DoE-Based Optimization of Electrochemical Reduction of L-Cystine at Metal Cathodes

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Design of experiment (DoE) is a powerful statistical tool in establishing improved chemical processes. An optimization and scale-up of the electrochemical reduction of L-cystine to L-cysteine is presented. Subsequent to an electrode screening of 17 metals and alloys in divided batch-type cells, the lead electrode was selected for a systematic optimization in flow cells with a geometric cathodic surface area ranging from 10 to 100 cm(2). Using two consecutive factorial designs, parameters like substrate concentration, current density, electrode gap, amount of applied charge, and number of cell passages were screened for significant effects onto the L-cystine conversion. A multiresponse optimization combining the product conversion and Faradaic efficiency was performed to account for economic considerations.

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来源
《Organic process research & development》 |2021年第12期|2622-2630|共9页
作者
Seidler Johannes; Bernhard Rebecca; Haufe StefanNeff CarolineGaertner TobiasWaldvogel Siegfried R.;
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作者单位

ESy Labs GmbH;

Wacker Chem AG;

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原文格式 PDF
正文语种英语
中图分类化学工业;
关键词
reduction; disulfides; cathodes; cysteine; design of experiment; LEADED BRONZE; L-CYSTEINE; DEHALOGENATION; CELL;

From Screening to Scale-Up: The DoE-Based Optimization of Electrochemical Reduction of L-Cystine at Metal Cathodes

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