Enhance the Bioactivity and Osseointegration of the Polyethylene-Terephthalate-Based Artificial Ligament via Poly(Dopamine) Coating with Mesoporous Bioactive Glass

Yu Bin; Pei Peng; Yu BaoqingLi DejianZhang XuHuang JianmingDing HuifengChen ShiyiZhu Yufang

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Enhance the Bioactivity and Osseointegration of the Polyethylene-Terephthalate-Based Artificial Ligament via Poly(Dopamine) Coating with Mesoporous Bioactive Glass

机译：Enhance the Bioactivity and Osseointegration of the Polyethylene-Terephthalate-Based Artificial Ligament via Poly(Dopamine) Coating with Mesoporous Bioactive Glass

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abstract_textpThe objective of this study is to study the bioactivity and osseointegration of polyethylene-terephthalate-based artificial ligament coated with mesoporous bioactive glass (MBG) via polydopamine (PDA) in vitro and in vivo. In vitro, the OD value of MC3T3-E1 cells on PDA-MBG modified grafts is around 108% higher than that on pure PET after 5 days of culturing. The ALP activity of the PDA-MBG group is about 1.5 times higher than that of the control group after 7 days of culturing. In the in vivo study, the results demonstrated that more newly formed bone tissue was found and the ultimate failure load increased in the PDA-MBG coating group. In conclusion, PDA and MBG coating improves the surface bioactivity of the polyethylene-terephthalate-based artificial ligament and enhances the osseointegration within a bone tunnel./p/abstract_text

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《advanced engineering materials》 |2017年第5期|共9页
作者
Yu Bin; Pei Peng; Yu BaoqingLi DejianZhang XuHuang JianmingDing HuifengChen ShiyiZhu Yufang;
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作者单位

Fudan Univ, Pudong Med Ctr, Dept Orthopaed, Shanghai Pudong Hosp, 2800 Gongwei Rd, Shanghai 201399, Peoples R China;

Univ Shanghai Sci & Technol, Sch Mat Sci & Engn, 516 Jungong Rd, Shanghai 200093, Peoples R China;

Fudan Univ, Huashan Hosp, Dept Sports Med, 12 Wulumuqi Zhong Rd, Shanghai 200040, Peoples R China;

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正文语种英语
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ANTERIOR CRUCIATE LIGAMENT; IN-VITRO; OSTEOGENIC DIFFERENTIATION; GRAFT OSSEOINTEGRATION; SURFACE MODIFICATION; IONIC PRODUCTS; FOLLOW-UP; BONE; RECONSTRUCTION; ANGIOGENESIS;

Enhance the Bioactivity and Osseointegration of the Polyethylene-Terephthalate-Based Artificial Ligament via Poly(Dopamine) Coating with Mesoporous Bioactive Glass

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