Polydimethylsiloxane-customized nanoplatform for delivery of antidiabetic drugs

Ahmed Gedawy; Crispin R Dass; Hani Al-Salami

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Polydimethylsiloxane-customized nanoplatform for delivery of antidiabetic drugs

机译：Polydimethylsiloxane-customized nanoplatform for delivery of antidiabetic drugs

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Aim: To develop a new self-emulsified silicon-grafted-alginate platform for pharmaceutical delivery. The produced biocompatible polymeric blend would be used to encapsulate metformin by a vibrational jet-flow ionotropic gelation process. Materials & methods: Polydimethylsiloxane was homogenized with alginate to prepare a stable polymeric mixture to which metformin was added. A metformin-loaded polymeric vehicle was then pumped through Buchi B-390 into CaCl2 to produce microcapsules. Results & conclusion: The platform showed a powerful, pseudoplastic thixotropic and demonstrated strong, efficient and wide applications of polydimethylsiloxane-customized technology in drug delivery and stability. A substantial improvement in drug loading, encapsulation efficiency and flow properties were noticed in siliconized microcapsules compared with the control.

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来源
《Therapeutic delivery》 |2020年第7期|415-429|共15页
作者
Ahmed Gedawy; Crispin R Dass; Hani Al-Salami;
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作者单位

School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin;

Biotechnology and Drug Development Research Laboratory, Curtin Health Innovation Research Institute;

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原文格式 PDF
正文语种英语
中图分类临床医学;
关键词
alginate; antidiabetics; delivery; encapsulation; ionic gelation; metformin; organosilicon; PDMS; platform;

Polydimethylsiloxane-customized nanoplatform for delivery of antidiabetic drugs

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