Potent adjuvant effect elicited for tumor immunotherapy by a liposome conjugated pH-sensitive polymer and dendritic cell-targeting Toll-like-receptor ligand

Watanabe Shunichi; Yuba Eiji; Akazawa TakashiWijewardana ViskamKakihara YukaAzuma AyakaHagimori KenjiKanegi RyojiHatoya ShingoInoue NorimitsuInaba ToshioSugiura Kikuya

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Potent adjuvant effect elicited for tumor immunotherapy by a liposome conjugated pH-sensitive polymer and dendritic cell-targeting Toll-like-receptor ligand

机译：Potent adjuvant effect elicited for tumor immunotherapy by a liposome conjugated pH-sensitive polymer and dendritic cell-targeting Toll-like-receptor ligand

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The generation of DCs with augmented functions is a strategy for obtaining satisfactory clinical outcomes in tumor immunotherapy. We developed a novel synthetic adjuvant comprising a liposome conjugated with a DC-targeting Toll-like-receptor ligand and a pH-sensitive polymer for augmenting cross presentation. In an in vitro study using mouse DCs, these liposomes were selectively incorporated into DCs, significantly enhanced DC function and activated immune responses to present an epitope of the incorporated antigen on the major histocompatibility complex class I molecules. Immunization of mice with liposomes encapsulating a tumor antigen significantly enhanced antigen-specific cytotoxicity. In tumor-bearing mice, vaccination with liposomes encapsulating a tumor antigen elicited complete tumor remission. Furthermore, vaccination significantly enhanced cytotoxicity, targeting not only the vaccinated antigen but also the other antigens of the tumor cell. These results indicate that liposomes are an ideal adjuvant to develop DCs with considerably high potential to elicit antigen-specific immune responses; they are a promising tool for cancer therapy with neoantigen vaccination. (c) 2022 Elsevier Ltd. All rights reserved.

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《Vaccine》 |2022年第10期|1448-1457|共10页
作者
Watanabe Shunichi; Yuba Eiji; Akazawa TakashiWijewardana ViskamKakihara YukaAzuma AyakaHagimori KenjiKanegi RyojiHatoya ShingoInoue NorimitsuInaba ToshioSugiura Kikuya;
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Osaka Prefecture Univ;

Osaka Int Canc Inst;

IAEAWakayama Med Univ;

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原文格式 PDF
正文语种英语
中图分类医学免疫学;
关键词
Tumor immunotherapy; Dendritic cells; Liposome; pH-sensitive polymer; Toll-like-receptor ligand; Cross-presentation; LUNG-CANCER; ANTIGEN; THERAPY; VACCINE;

Potent adjuvant effect elicited for tumor immunotherapy by a liposome conjugated pH-sensitive polymer and dendritic cell-targeting Toll-like-receptor ligand

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