SUMMARYThethaplotypes of mouse chromosome 17 bear a number of interesting mutations and rearrangements, some of which map close to theH‐2complex. Since there are manyH‐2class I genes of unknown function, we have investigated their arrangement inthaplotypes using genomic Southern blots. We present a detailed chart of theH‐2w30(tw12)complex, and compare it with the arrangement in otherthaplotypes and standard mouse haplotypes. The chart shows duplications, deletions, and reshuffling of conserved and divergent regions. The two major features of thetarrangement‐large deletions in the Qa and Tla regions–have analogues in some standard strains, so it is unlikely that these deletions are responsible fort‐specific phenotypes. The differences betweentand standard mouse strains are similar, in nature and in degree, to those between different stand
展开▼
