P53 is a tumor suppressor gene encoded by the TP53 gene which, in response to stress, regulates transcription of target genes. The loss of functional tumor suppressor genes leads to overactivation of ONCA genes. Dr. David Sallman of Moffitt Cancer Center speaks about the impact TP53 mutation has on the prognosis of myelodysplastic syndrome (MDS), outcomes of hypomethylating agent (HMA)-based therapy vs. stem cell transplantation, and novel therapies targeting TP53.
展开▼
