SUMMARYAge‐dependent changes, during adult life, in suppressor capacity and B cell responsiveness have been known for some time. In this paper, an age dependent change in helper function, is being reported. A Th‐2 type of helper effect can be observed in tissue culture of spleen cells from animals sensitized with a macromolecule. An indirect plaque‐forming response to the hapten occurs when the spleen cells are exposed to the sensitizing macromoleculeandto the hapten conjugated to a carrier, structurally unrelated to the sensitizing macromolecule. There is considerable polymorphism in the age at which this effect is first demonstrable and at which it reaches mature levels. Mice of inbred strains, with various defects in the suppressor cell circuit (SJL/J, MRL/MpJ‐lpr/lpr, BXSB/MpJ) show an accelerated development of Th‐2 helper capacity in the indirect plaque‐formi
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