Beyond luciferase-luciferin system: Modification, improved imaging and biomedical application

Jiang Yiyi; Shi Xiaorui; Tang ChuWang Fu

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Beyond luciferase-luciferin system: Modification, improved imaging and biomedical application

机译：Beyond luciferase-luciferin system: Modification, improved imaging and biomedical application

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The bioluminescence signal generated by the luciferase-luciferin interaction, exploited for real-time and continuous monitoring of numerous biochemical processes in living cells and animals, is the foundation for in vivo bioluminescence imaging (BLI). However, many in vivo BLI application remains constrained due to the limited photon production and sensitivity in deep tissues. To obtain brighter bioluminescence images, various modified luciferase-luciferin emitting systems were developed by mutating suitable luci-ferase enzyme sites, replacing the substrate with its analogs, or inserting unnatural amino acids. In this review, we describe recent advances in modifying natural luciferase reporter systems to improve the sen-sitivity of in vivo BLI and extend the biomedical applications. (c) 2023 Elsevier B.V. All rights reserved.

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《Coordination chemistry reviews》 |2023年第4期|215045.1-215045.24|共24页
作者
Jiang Yiyi; Shi Xiaorui; Tang ChuWang Fu;
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作者单位

Xidian Univ;

Xidian Univ||Shaanxi Inst Int Trade & Commerce;

Xidian Univ||Shaanxi Inst Int Trade & Commerce||Xi An Jiao Tong Univ;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种英语
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关键词
Bioluminescence imaging; Luciferase-luciferin; Modification; In vivo imaging;

Beyond luciferase-luciferin system: Modification, improved imaging and biomedical application

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