Interleukin-1beta and interleukin-8 concentrations in the lower uterine segment during parturition at term.

Winkler M; Fischer DC; Hlubek Mvan-de-Leur EHaubeck HDRath W

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Interleukin-1beta and interleukin-8 concentrations in the lower uterine segment during parturition at term.

机译：Interleukin-1beta and interleukin-8 concentrations in the lower uterine segment during parturition at term.

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OBJECTIVE: To assess the roles of interleukin-1beta, interleukin-8, and fibroblasts in the lower uterine segment during parturition. METHODS: Lower uterine segment biopsy specimens were obtained from 36 women undergoing cesarean delivery at various stages of cervical dilation (less than 2 cm, n = 8; 2 to less than 4 cm, n = 9; 4-6 cm, n = 10; more than 6 cm, n = 9). The concentrations of interleukin-1beta and interleukin-8 in protein extracts prepared from the tissue samples were measured by enzyme immunoassays. The effect of incubation with interleukin-1beta (30 U/mL) on interleukin-8 secretion by lower uterine segment fibroblasts in vitro also was determined. RESULTS: The median interleukin-1beta concentration in the specimens increased from 1.3 pg/mg of total protein at less than 2 cm of dilation to 22.2 pg/mg of total protein at 4-6 cm of dilation (P < .05). No further increase was detectable after 6 cm of dilation. The interleukin-8 concentration increased from 17.2 pg/mg of total protein at less than 2 cm of dilation to 2080.7 pg/mg of total protein at 4-6 cm of dilation (P < .05), thus paralleling the increase in interleukin-1beta concentration. Interleukin-1beta induced a significant increase in interleukin-8 secretion by fibroblasts in vitro, from 0.8 ng/10(6) cells to 35.6 ng/10(6) cells. CONCLUSION: The increase in interleukin-8 concentration in the lower uterine segment during parturition may be induced by interleukin-1beta and fibroblasts may be one of the sources of this interleukin-8.

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《Obstetrics and Gynecology: Journal of the American College of Obstetricians and Gynecologists》 |1998年第6期|945-949|共5页
作者
Winkler M; Fischer DC; Hlubek Mvan-de-Leur EHaubeck HDRath W;
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作者单位

Department of Obstetrics and Gynecology and the Institute for Clinical Chemistry and Pathobiochemistry, University Hospital, Technical University, Aachen, Germany.;

ilot.msu.edu;

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原文格式 PDF
正文语种英语
中图分类妇产科学;
关键词
Interleukin-1; Interleukin-8; Labor; Uterus; 白细胞介素1; 白细胞介素8; 分娩; 子宫;

Interleukin-1beta and interleukin-8 concentrations in the lower uterine segment during parturition at term.

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