Pharmacokinetics and pharmacodynamics of oseltamivir in neonates, infants and children

StandingJ.F.; TsoliaM.; LutsarI.

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Pharmacokinetics and pharmacodynamics of oseltamivir in neonates, infants and children

机译：Pharmacokinetics and pharmacodynamics of oseltamivir in neonates, infants and children

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Pharmacokinetic-pharmacodynamic (PKPD) studies have the potential to yield useful information on whether and how a drug works, and what dose to use. This approach is often best suited to situations where dose-response relationships need to be elucidated and where randomisation is not feasible. Children make up around one third of cases during influenza outbreaks, and are more susceptible to certain complications such as otitis media. Despite this, high-quality randomised controlled trials (RCT) of antiviral therapies such as oseltamivir have not been performed, leaving open the question of whether and at what dose to use. This review therefore focusses on the available PKPD data in children. Oseltamivir has complex PK which requires modelling to properly understand the relationship between dose and concentration with time, and there is a lack of clarity on appropriate pharmacodynamic endpoints. Following a general overview of oseltamivir PKPD, this review seeks to summarise the available paediatric PKPD data, identify gaps in our knowledge and priorities for future research.

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《Infectious disorders drug targets》 |2013年第1期|6-14|共9页
作者
StandingJ.F.; TsoliaM.; LutsarI.;
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作者单位

Infectious Diseases and Microbiology Unit, University College London, Institute of Child Health;

Second Department of Paediatrics, National and Kapodistrian University of Athens School of Medicine;

Institute of Microbiology, Estonia, University of Tartu, Estonia;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Children; Influenza; Neuraminidase inhibitors; Oseltamivir; Pharmacodynamics; Pharmacokinetics;

Pharmacokinetics and pharmacodynamics of oseltamivir in neonates, infants and children

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