Postmenopausal hormone replacement therapy: effects on normal mammary gland in humans and in a mouse postmenopausal model.

Haslam SZ; Osuch JR; Raafat AMHofseth LJ

首页> 外文期刊>Journal of mammary gland biology and neoplasia >Postmenopausal hormone replacement therapy: effects on normal mammary gland in humans and in a mouse postmenopausal model.

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Postmenopausal hormone replacement therapy: effects on normal mammary gland in humans and in a mouse postmenopausal model.

机译：Postmenopausal hormone replacement therapy: effects on normal mammary gland in humans and in a mouse postmenopausal model.

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摘要

Endogenous estrogen exposure has long been implicated in the causation of breast cancer through a mechanism of epithelial cell proliferation. Whether estrogen, progesterone, or both exhibit mitogenic activity and promote carcinogenesis in the human breast has been the subject of considerable debate. The purpose of this review article is to examine the evidence for the effects of hormone replacement therapy in its various forms on the biology of the postmenopausal breast both in humans and in an animal model, and to identify the gaps in knowledge that research will need to address to further understand this complex issue.

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来源
《Journal of mammary gland biology and neoplasia》 |2002年第1期|93-105|共13页
作者
Haslam SZ; Osuch JR; Raafat AMHofseth LJ;
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作者单位

Department of Physiology, Michigan State University, East Lansing 48824, USA. shaslam;

artners.org;

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原文格式 PDF
正文语种英语
中图分类外科学各论;肿瘤学;
关键词
Breast; Hormone Replacement Therapy; Postmenopausal state; Models; Laboratory mice; 乳房; 激素替代疗法;

Postmenopausal hormone replacement therapy: effects on normal mammary gland in humans and in a mouse postmenopausal model.

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