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>Prostaglandin F2αstimulates phosphatidylinositol turnover and increases the cellular content of 1,2‐diacylglycerol in confluent resting swiss 3T3 cells
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Prostaglandin F2αstimulates phosphatidylinositol turnover and increases the cellular content of 1,2‐diacylglycerol in confluent resting swiss 3T3 cells
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机译：Prostaglandin F2αstimulates phosphatidylinositol turnover and increases the cellular content of 1,2‐diacylglycerol in confluent resting swiss 3T3 cells
AbstractProstaglandin F2α(PGF2α); which stimulates DNA synthesis in resting 3T3 cells, also stimulates the incorporation of [32P]PO4into phosphatidylinositol. The effect is selective for PGF2αwhen compared with PGE1, PGE2, and PGF2α. Epidermal growth factor (EGF) also stimulates DNA synthesis but does not affect phosphatidylinositol turnover. PGE1, which acts synergistically with PGF2αto enhance DNA synthesis, does not affect the ability of PGF2αto enhance the incorporation of [32P]PO4into phosphatidylinositol. PGF2αalso causes a small increase in the cellular content of 1,2‐diacylglycerol. This effect is not shared by EGF or PGE1. Stimulation of phosphatidylinositol metabolism resulting in an increase in the cellular content of 1,2‐diacylglycerol may thus constitute an event in the pathway leading to the initiation of DNA synthesis in which PGF2αdiffers in its acti
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