Utility of a patient-reported outcome in measuring functional impairment during autologous stem cell transplant in patients with multiple myeloma

Nina Shah; Qiuling Shi; Sergio GiraltLoretta WilliamsQaiser BashirMuzaffar QazilbashRichard E. ChamplinCharles S. CleelandXin Shelley Wang

首页> 外文期刊>Quality of life research: An international journal of quality of life aspects of treatment, care and rehabilitation >Utility of a patient-reported outcome in measuring functional impairment during autologous stem cell transplant in patients with multiple myeloma

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Utility of a patient-reported outcome in measuring functional impairment during autologous stem cell transplant in patients with multiple myeloma

机译：Utility of a patient-reported outcome in measuring functional impairment during autologous stem cell transplant in patients with multiple myeloma

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Abstract Background We aimed to determine the utility of a patient-reported outcome (PRO) as it relates to patient performed testing (PPT) for measuring functional status in multiple myeloma patients after autologous hematopoietic stem cell transplantation (auto-HCT). Methods Symptom interference on walking (a PRO) was measured by the MD Anderson Symptom Inventory (MDASI). PPT was assessed via 6-min walk test (6MWT). Mixed effects modeling was used to examine (1) the longitudinal relationship between the MDASI score and 6MWT distance and (2) the MDASI scores between patients who did or did not complete the 6WMT. Receiver operating characteristic (ROC) curve analysis was performed to quantify the construct validity of the PRO by differentiating performance status. Results Seventy-nine patients were included. Mean 6MWT distance significantly correlated with MDASI-walking interference score (PRO) over the first month of auto-HCT (est?=?6.09, p ?=?0.006). There was a significantly higher completion rate for MDASI versus 6MWT at each time point ( p ? p ? p ?=?0.003). Conclusion The PRO of MDASI-walking interference is a valid physical functioning measure, correlating with an objective functional measure (6MWT) in MM patients undergoing auto-HCT. As patients with poorer functional status during therapy are less likely to complete PPT, this PRO may offer a more practical quantitative measure of functioning in patients.

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《Quality of life research: An international journal of quality of life aspects of treatment, care and rehabilitation》 |2018年第4期|979-985|共7页
作者
Nina Shah; Qiuling Shi; Sergio GiraltLoretta WilliamsQaiser BashirMuzaffar QazilbashRichard E. ChamplinCharles S. CleelandXin Shelley Wang;
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Department of Medicine, University of California San Francisco;

Department of Symptom Research, The University of Texas MD Anderson Cancer Center;

Department of Medicine, Memorial Sloan-Kettering Cancer CenterDepartment of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center;

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正文语种英语
中图分类医药、卫生;
关键词
Patient-reported outcomes (PRO); Patient performed testing (PPT); MD Anderson Symptom Inventory (MDASI); Functional status; Auto-HCT;

Utility of a patient-reported outcome in measuring functional impairment during autologous stem cell transplant in patients with multiple myeloma

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