Porous Poly (ε-caprolactone) Nerve Guide Filled with Porous Gelatin Matrix for Nerve Tissue Engineering

Chiara Tonda-Turo; Chiara Audisio; Sara GnaviValeria ChionoPiergiorgio GentileStefania RaimondoStefano GeunaIsabelle PerroteauGianluca Ciardelli

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Porous Poly (ε-caprolactone) Nerve Guide Filled with Porous Gelatin Matrix for Nerve Tissue Engineering

机译：Porous Poly (ε-caprolactone) Nerve Guide Filled with Porous Gelatin Matrix for Nerve Tissue Engineering

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The preparation and characterization of PCL guides filled with a porous matrix of a freeze-dried, genipin-crosslinked gelatin sponge (GL/GP) is described. Porous guides are obtained by dip coating a rotating mandrel with a PCL/PEO blend solution followed by PEO solvent extraction. PCL/PEO 60/40 is selected as the optimal composition to obtain model porous membranes with suitable morphological properties to ensure nutrient permeation and moderate stiffness. GL/GP sponges show increased mechanical strength and water stability, compared to uncrosslinked GL sponges. GL/GP in the form of films, sponges and internal fillers support the in vitro adhesion and proliferation of Schwann like cells.

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来源
《Advanced Engineering Materials》 |2011年第5期|B151-B164|共14页
作者
Chiara Tonda-Turo; Chiara Audisio; Sara GnaviValeria ChionoPiergiorgio GentileStefania RaimondoStefano GeunaIsabelle PerroteauGianluca Ciardelli;
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作者单位

Department of Mechanics, Politecnico di Torino;

Department of Animal and Human Biology, University of Turin;

Department of Clinical and Biological Sciences, University of Turin;

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正文语种英语
中图分类工程材料学;
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Porous Poly (ε-caprolactone) Nerve Guide Filled with Porous Gelatin Matrix for Nerve Tissue Engineering

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