Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

Chang Jing; An Qiong; Xie YunLiu WentaoXu PengHao WeiyuWan Bin

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Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

机译：Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

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摘要

Asa widely used insecticide in the agricultural fields,the risk of flufiprole to the terrestrial organism Eremias argus is elevated under global warming. As a phenylpyrazole insecticide, flufiprole is an importantsubstitutefor fipronil in the agricultural field of China. However, its bioaccumulationand metabolism in terrestrial organisms especially in the lizardsliving in the agricultural area have rarely been investigated. Asan ectothermic animal, lizards are also sensitive to temperature changes.Considering global warming, this study measured bioaccumulation, metabolism,and hepatotoxicity of flufiprole in the Chinese native lizard (Eremias argus) under different temperature stresses.Lizards exposed to flufiprole-contaminated soil adsorbed flufiprolethrough the skin and flufiprole was preferred to accumulate in lizardliver and brain. The oxidation product fipronil sulfone was the mainmetabolite of flufiprole in both lizard liver and human liver microsomes,which were mainly metabolized by lizard CYP3A19 or human CYP3A4. Thefipronil sulfone concentration increased with increased temperaturein lizard tissues. In addition, more serious oxidative damage wasshown under higher temperature as the glutathione (GSH), malondialdehyde(MDA), and 8-hydroxy-2 & PRIME;-deoxyguanosine (8-OHdG) levels in lizardsincreased with increased temperature after flufiprole exposure. Flufiproleexposure also induced lizard liver lesions, and these lesions becamemore serious in the higher-temperature groups. This study providednew insights into the risk assessment of flufiprole in lizards underglobal warming.

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《Environmental Science & Technology: ES&T》 |2023年第31期|11612-11625|共14页
作者
Chang Jing; An Qiong; Xie YunLiu WentaoXu PengHao WeiyuWan Bin;
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作者单位

Chinese Acad Sci;

Chinese Acad Inspect & Quarantine;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
reptiles; global warming; metabolism; oxidative damage; phenylpyrazole insecticide; TISSUE DISTRIBUTION; OXIDATIVE STRESS; FIPRONIL; TOXICITY; EXPOSURE; 8-HYDROXY-2'-DEOXYGUANOSINE; ENANTIOMERS; PESTICIDE; RESPONSES; REPTILES;

Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

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