AbstractWe describe a patient who presented with polyarthritis, pleurisy, rash, and a positive antinuclear antibody result after 5 years of D‐penicillamine therapy. D‐penicillamine‐induced antinuclear antibodies were mainly high‐titer IgG directed against the (H2A‐H2B)‐DNA complex. Weak IgM activity with H1 and H2B was also observed. Withdrawal of D‐penicillamine therapy resulted in improvement in clinical symptoms and gradual resolution of serologic
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