A considerable wealth of new information was gained on the metabolism and hepatotoxicity of ethanol during 1991. Much progress has been made on the elucidation of pathways of ethanol metabolism, including gastric alcohol dehydrogenase and associated alcohol-drug interactions, as well as genetic determinants of hepatic alcohol metabolism and associated changes of relevance to alcoholic liver injury. Significant, though less impressive, advances have been made in the field of prevention and treatment.
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