Prognostic value of patient-reported symptom interference in patients with late-stage lung cancer

BarneyB.J.; WangX.S.; LuC.LiaoZ.JohnsonV.E.CleelandC.S.MendozaT.R.

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Prognostic value of patient-reported symptom interference in patients with late-stage lung cancer

机译：Prognostic value of patient-reported symptom interference in patients with late-stage lung cancer

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Purpose: Patient-reported outcomes (PROs) have been found to be significant predictors of clinical outcomes such as overall survival (OS), but the effect of demographic and clinical factors on the prognostic ability of PROs is less understood. Several PROs derived from the 12-item Short-Form Health Survey (SF-12) and M. D. Anderson Symptom Inventory (MDASI) were investigated for association with OS, with adjustments for other factors, including performance status. Methods: A retrospective analysis was performed on data from 90 patients with stage IV non-small cell lung cancer. Several baseline PROs were added to a base Cox proportional hazards model to examine the marginal significance and improvement in model fit attributable to the PRO: mean MDASI symptom interference level; mean MDASI symptom severity level for five selected symptoms; SF-12 physical and mental component summaries; and the SF-12 general health item. Bootstrap resampling was used to assess the robustness of the findings. Results: The MDASI mean interference level had a significant effect on OS (p = 0.007) when the model was not adjusted for interactions with other prognostic factors. Further exploration suggested the significance was due to an interaction with performance status (p = 0.001). The MDASI mean symptom severity level and the SF-12 physical component summary, mental component summary, and general health item did not have a significant effect on OS. Conclusions: Symptom interference adds prognostic information for OS in advanced lung cancer patients with poor performance status, even when demographic and clinical prognostic factors are accounted for.

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《Quality of life research: An international journal of quality of life aspects of treatment, care and rehabilitation》 |2013年第8期|2143-2150|共8页
作者
BarneyB.J.; WangX.S.; LuC.LiaoZ.JohnsonV.E.CleelandC.S.MendozaT.R.;
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作者单位

Department of Symptom Research (Unit 1450), University of Texas MD Anderson Cancer Center, Unit;

Department of Mathematics and Statistics, Kennesaw State University, Kennesaw, Georgia;

Department of Thoracic/Head and Neck Medical Oncology (Unit 432), University of Texas MD AndersonDepartment of Radiation Oncology (Unit 97), University of Texas MD Anderson Cancer Center, 1515Department of Biostatistics (Unit 1411), University of Texas MD Anderson Cancer Center, 1515;

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正文语种英语
中图分类医药、卫生;
关键词
Interference; Lung cancer; Symptoms;

Prognostic value of patient-reported symptom interference in patients with late-stage lung cancer

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