...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BioMetals: An International Journal on the Role of Metal Ions in Biology, Biochemistry and Medicine >Proteomic detection of changes in protein synthesis induced by lanthanum in BGC-823 human gastric cancer cells
【24h】

Proteomic detection of changes in protein synthesis induced by lanthanum in BGC-823 human gastric cancer cells

机译：Proteomic detection of changes in protein synthesis induced by lanthanum in BGC-823 human gastric cancer cells

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

There is increasing interest in the use of rare earth elements in medicine. However, the biological mechanism of action of this metal ion remains unclear. In the present Study, changes in protein synthesis induced by lanthanum in BGC-823 human gastric cancer cells were investigated. The proteins were separated using two-dimensional polyacrylamide gel electrophoresis and four proteins were significantly affected by lanthanum treatment when compared to an untreated control. Among them, one was down-regulated and three were up-regulated. Of these, three were successfully identified as RHOJ, CSP6 and MPI2 with peptide mass fingerprinting using matrix-assisted laser desorption/ionization time of flight mass spectrometer (MALDI-TOF-MS) after in-gel trypsin digestion. Among them, RHOJ was down-regulated and CSP6 and MPI2 were up-regulated. The three proteins are involved in various cellular functions, which are correlated with the regulation of cell morphology, gene transcription and cell cycle, respectively. It is suggested that the possible involvement of rare earth elements in the growth arrest Of tumor cells is significantly associated with the differential protein expression induced by rare earth ions.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号