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Targeting PPARalpha in Alzheimer's Disease

机译：Targeting PPARalpha in Alzheimer's Disease

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Background: The molecular mechanisms underlying Alzheimer's disease (AD) are yet to be fully elucidated. The so-called "amyloid cascade hypothesis" has long been the prevailing paradigm for causation of disease, and is today being revisited in relation to other pathogenic pathways, such as oxidative stress, neuroinflammation and energy dysmetabolism. The peroxisome proliferator-activated receptors (PPARs) are expressed in the central nervous system (CNS) and regulate many physiological processes, such as energy metabolism, neurotransmission, redox homeostasis, autophagy and cell cycle. Among the three isotypes (alpha, beta/delta, gamma), PPAR gamma role is the most extensively studied, while information on alpha and beta/delta are still scanty. However, recent in vitro and in vivo evidence point to PPAR alpha as a promising therapeutic target in AD.

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