In Situ Enzyme-Induced Self-Assembly of Antimicrobial-Antioxidative Peptides to Promote Wound Healing

Runxin Teng; Yuying Yang; Zhuo ZhangKexin YangMin SunChang LiZhen FanJianzhong Du

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In Situ Enzyme-Induced Self-Assembly of Antimicrobial-Antioxidative Peptides to Promote Wound Healing

机译：In Situ Enzyme-Induced Self-Assembly of Antimicrobial-Antioxidative Peptides to Promote Wound Healing

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Antimicrobial peptides (AMPs) with dual intrinsic antibacterial and antioxidativefunctions have emerged as promising choice to cure infected wound.However, the most widely applied approach to endow AMPs with antioxidativefunction is to combine with antioxidative moieties, which may affectthe spatial structure and physiological stability of AMPs. Herein, a new typeof AMPs with inherent desired stability, antibacterial activity, and reactiveoxygen species (ROS) scavenging is developed to effectively heal the infectedwound. This formulation is in situ formed at wound site by tyrosinasetriggeredoxidation and self-assembly of lyophilized antimicrobial peptideTrp-Arg-Trp-Arg-Trp-Tyr, providing enhanced stability and a fourfold andsevenfold increasement in antibacterial efficiency against E. coli and S. aureuscompared to peptide monomers. The antimicrobial peptide is first oxidizedand then assembled into nanoparticles. The melanin-like structure has beendemonstrated with efficient antioxidant properties, and the experimental datashow that peptide nanoparticles to scavenge superoxide radicals, hydroxylradicals, and H_2O_2. In vivo experiments confirmed that peptide nanoparticleseffectively heal infected wounds and obviously reduce ROS. Overall, theresearch provides a new approach to formulating antimicrobial peptides totreat wound with high healing efficiency.

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来源
《Advanced functional materials》 |2023年第23期|2214454.1-2214454.10|共10页
作者
Runxin Teng; Yuying Yang; Zhuo ZhangKexin YangMin SunChang LiZhen FanJianzhong Du;
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作者单位

Department of Polymeric MaterialsSchool of Materials Science and EngineeringTongji University4800 Caoan Road, Shanghai 201804, China;

Department of Orthopedics, Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072, China Institute for Advanced StudyTongji UniversityShanghai 200092, China;

Department of Polymeric MaterialsSchool of Materials Science and EngineeringTongji University4800 Caoan Road, Shanghai 201804, China Department of Orthopedics, Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072, China Inst;

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正文语种英语
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bacteria; in situ self-assemblies; peptides; tyrosinase; wound healing;

In Situ Enzyme-Induced Self-Assembly of Antimicrobial-Antioxidative Peptides to Promote Wound Healing

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