Aflatoxin B-1 when binds to DNA bases, cause DNA damage, thus, affects the functioning, growth, division, and control of cells. Oleuropein is a fundamental polyphenol founded in olive leaf, fruit, oil and has many benefits for human health. In this study, the possible effect of oleuropein was assessed against toxicity of aflatoxin B-1. For this purpose, the single cell gel electrophoresis and micronuclei assays were performed using the cells of human peripheral blood. As a result of this study, it was determined that oleuropein has not genotoxic effect and exhibited anti-genotoxic properties caused by aflatoxin B1 (with especially 625 mu M application) (p0.05). On this basis, the observed anti-genotoxic effect of oleuropein against aflatoxin B-1 may occur as oleuropein has sufficient capability to reduce the lipid peroxidation and inhibit the loss of membrane integrity.
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