Associations between the prevalence of chronic hepatitis B among people who inject drugs and country‐level characteristics: An ecological analysis

Anjalee Syangbo; Matthew Hickman; Samantha Colledge‐FrisbyJanni LeungJason GrebelySarah LarneyLouisa DegenhardtAdam Trickey

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Associations between the prevalence of chronic hepatitis B among people who inject drugs and country‐level characteristics: An ecological analysis

机译：Associations between the prevalence of chronic hepatitis B among people who inject drugs and country‐level characteristics: An ecological analysis

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Abstract Introduction Globally, hepatitis B virus (HBV) is a leading cause of liver disease. People who inject drugs (PWID) are at greater risk than the general population of contracting HBV. This risk could depend on societal factors in different countries. We investigated the associations between country‐level chronic HBV prevalence in PWID with national indicators of development and prevalence of HIV and hepatitis C virus (HCV). Methods We used global systematic review data on chronic HBV prevalence (hepatitis B surface antigen‐positive) among PWID and country‐level sociodemographic characteristics from online databases. National random‐effects meta‐analysis estimates of HBV prevalence were the outcome in linear regression models testing for associations with country‐level characteristics. Results The study included 131,710 PWID from 304 estimates in 55 countries: the pooled HBV prevalence among PWID in the countries analysed was 4.5% (95% CI 3.9–5.1), the highest regional pooled prevalence was in East and Southeast Asia (17.6% [13.3–22.3]), and the lowest was in Western Europe (1.7% [1.4–2.1]). In multivariable models, no indicators of development were associated with HBV prevalence, but there was evidence of positive associations between HBV prevalence in the general population and among PWID, and evidence of HIV and HCV prevalence in PWID being associated with HBV prevalence in PWID: multivariable coefficients 0.03 (95% CI 0.01–0.04); p?

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《Drug and alcohol review》 |2023年第3期|569-581|共13页
作者
Anjalee Syangbo; Matthew Hickman; Samantha Colledge‐FrisbyJanni LeungJason GrebelySarah LarneyLouisa DegenhardtAdam Trickey;
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作者单位

Population Health Sciences,University of Bristol;

National Drug and Alcohol Research Centre, UNSW Sydney;

Kirby Institute, UNSW Sydney;

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正文语种英语
中图分类药学;
关键词
ecological; hepatitis B virus; people who inject drugs; prevalence;

Associations between the prevalence of chronic hepatitis B among people who inject drugs and country‐level characteristics: An ecological analysis

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