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首页> 外文期刊>Journal of environmental science and health, Part A. Toxic/hazardous substances & environmental engineering >Blood lead level (BLL), δ-aminolevulinic acid dehydratase activity (ALAD), hemoglobin (Hb) and hematocrit (hct) in primary school-children and adult residents living in smelter rural areas in Kosovo
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Blood lead level (BLL), δ-aminolevulinic acid dehydratase activity (ALAD), hemoglobin (Hb) and hematocrit (hct) in primary school-children and adult residents living in smelter rural areas in Kosovo

机译：Blood lead level (BLL), δ-aminolevulinic acid dehydratase activity (ALAD), hemoglobin (Hb) and hematocrit (hct) in primary school-children and adult residents living in smelter rural areas in Kosovo

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The objective of this study was to investigate the effects of chronic environmental lead (Pb) exposure in blood lead level (BLL), delta-aminolevulinic acid dehydratase (ALAD) activity, hemoglobin (Hb) amount and hematocrit (Hct) value in primary schoolchildren and adults. Blood was obtained for BLL, ALAD, Hb and Hct measurements in 23 primary schoolchildren (girls and boys) and 117 adult residents (women and men) living in three villages (Kelmend, Boletin and Zhazhe) defined by concentric circles 2, 3 and 5 km in radius drawn around from the smelter-refinery complex "Trepca"in Zvecan and in Koliq village 40 km away. As expected, BLLs were substantially higher in the schoolchildren from smelter area compared with control (11 +/- 4.2 mu g/L and 6.9 +/- 1.6 mu g/L respectively) and in adult residents from Kelmend, Boletin and Zhazhe (24 +/- 11.8, 12 +/- 4.5, 11 +/- 5.4 and 8.0 +/- 2.8 mu g/L respectively). Blood ALAD activity of children in Zhazhe is 16% inhibited compared to control and blood ALAD activity in adults in villages from smelter area is 32, 3%, 48, 4% and 17, 8% inhibited compared to control. There is no difference of Hb and Hct values in schoolchildren from Zhazhe and in adult residents from Kelmend and Zhazhe compared with control. Results of this study provide evidence of moderate inverse correlation between BLL and ALAD activity in both examined cohorts from smelter area. The inhibition of ALAD activity in primary schoolchildren and adults occurred at blood lead levels 24 mu g/L; consequently it can cause an increase of delta- Aminolevulinic acid.

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