Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding

Nancy Podevin; Howard V. Davies; Frank Hartung

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Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding

机译：Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding

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Conventional plant breeding exploits existing genetic variability and introduces new variability by mutagenesis. This has proven highly successful in securing food supplies for an ever-growing human population. The use of genetically modified plants is a complementary approach but all plant breeding techniques have limitations. Here, we discuss how the recent evolution of targeted mutagenesis and DNA insertion techniques based on tailor-made site-directed nucleases (SDNs) provides opportunities to overcome such limitations. Plant breeding companies are exploiting SDNs to develop a new generation of crops with new and improved traits. Nevertheless, some technical limitations as well as significant uncertainties on the regulatory status of SDNs may challenge their use for commercial plant breeding.

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来源
《Trends in biotechnology》 |2013年第6期|375-383|共9页
作者
Nancy Podevin; Howard V. Davies; Frank Hartung;
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作者单位

Julius Kuhn-lnstitut (JKI), Federal Research Centre for Cultivated Plants, Institute for Biosafety in Plant Biotechnology, Erwin-Baur-Str. 27, D-06484 Quedlinburg, Germany;

The European Food Safety Authority (EFSA), Via Carlo Magno 1A, Parma, Italy;

The James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种英语
中图分类普通生物学;
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Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding

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