SUMMARYMonoclonal anti‐Ia inhibition experiments were conducted to confirm and extend genetic mapping data ofI‐Agene control of immunity to human haemoglobin (Hb). It was found that theAβgene is of critical importance in conferring immunity to the α‐chain and β‐chain subunits of Hb. A possible involvement ofI‐Eregion genes in B10.D2 mice to β‐chain is discussed. Through the use of an α‐chain specific T cell clone data, is obtained indicating that an intact Ia.8+Aβchain is necessary for antigen p
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