The Relationship Between HIV Antibody Titer, HIV Viral Load, HIV p24 Antigen, and CD4 T-cell Count Among Iranian HIV-positive Patients  Bentham Science

Majedeh Moradbeigi; SeyedAhmad SeyedAlinaghi; Mansour SajadipourOmid DadrasEsfandiar ShojaeiParisa AhmadiSaeed BayanolhaghKazem BaesiMehrnaz Rasoolinejad

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The Relationship Between HIV Antibody Titer, HIV Viral Load, HIV p24 Antigen, and CD4 T-cell Count Among Iranian HIV-positive Patients Bentham Science

机译：The Relationship Between HIV Antibody Titer, HIV Viral Load, HIV p24 Antigen, and CD4 T-cell Count Among Iranian HIV-positive Patients Bentham Science

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Objective: This study aimed to simultaneously measure and assess the correlation betweenthe available HIV infection parameters including HIV antibody, p24 Antigen, CD4 cellcount, and viral load at the different stages of HIV disease among HIV-positive individuals inIran.Materials and Methods: Fifty HIV-positive individuals were classified into three stages (1, 2, and3) according to the HIV disease stages classification, available in Control of Disease and Prevention(CDC) guideline. 10 ml of the venous blood sample was collected to run the tests for HIV antibodyand p24 Ag levels, CD4 cell counts, and viral load. Pearson’s correlation test was employedto calculate the coefficients for the in-between correlation of different HIV parameters ineach stage.Results: Of 50 participants, 17 (34%), 25 (50%), and 8 (16%) patients belonged to stages 1, 2, and3, respectively. Sexual relationship was the main route of HIV transmission among the patients(36%); however, injecting drug use (20%) was also reported frequently. There was no significantcorrelation between the parameters of HIV disease in different stages in the present study.Conclusion: The findings showed no correlation between HIV parameters in the present study.Considering the fact that the association of HIV antibodies with HIV disease progression in infectedindividuals is independent of HIV-1 RNA levels, combined measurement of HIV-1 RNAand CD4 cell counts should be routinely carried out in HIV infected patients follow up.

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《Infectious disorders drug targets》 |2020年第5期|752-757|共6页
作者
Majedeh Moradbeigi; SeyedAhmad SeyedAlinaghi; Mansour SajadipourOmid DadrasEsfandiar ShojaeiParisa AhmadiSaeed BayanolhaghKazem BaesiMehrnaz Rasoolinejad;
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Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical;

Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors;

Department of Global Health and Socioepidemiology, Graduate School of Medicine, Kyoto UniversityChemistry Faculty, Khajenasir Toosi University of TechnologyHepatitis and AIDS Department, Pasteur Institute of Iran;

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正文语种英语
中图分类药学;
关键词
P24 Ag; HIV viral load; CD4 count; HIV antibody; correlation; HIV-1 RNA;

The Relationship Between HIV Antibody Titer, HIV Viral Load, HIV p24 Antigen, and CD4 T-cell Count Among Iranian HIV-positive Patients Bentham Science

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