Central Nervous System and its Disease Models on a Chip

Yi YoonYoung; Park JiSoo; Lim JaehoLee C. JustinLee Sang-Hoon

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Central Nervous System and its Disease Models on a Chip

机译：Central Nervous System and its Disease Models on a Chip

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Technologies for microfluidics and biological microelectromechanical systems have been rapidly progressing over the past decade, enabling the development of unique microplatforms for in vitro human central nervous system (CNS) and related disease models. Most fundamental techniques include manipulation of axons, synapses, and neuronal networks, and different culture conditions are possible, such as compartmental, co-culturing, and 3D. Various CNS disease models, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), epilepsy, N-methyl-D-aspartate receptor (NMDAR) encephalitis, migraine, diffuse axonal injury, and neuronal migration disorders, have been successfully established on microplatforms. In this review, we summarize fundamental technologies and current existing CNS disease models on microplatforms. We also discuss possible future directions, including application of these methods to pathological studies, drug screening, and personalized medicine, with 3D and personalized disease models that could generate more realistic CNS disease models.

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来源
《Trends in biotechnology》 |2015年第12期|762-776|共15页
作者
Yi YoonYoung; Park JiSoo; Lim JaehoLee C. JustinLee Sang-Hoon;
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作者单位

Hallym Univ, Coll Med, Dept Pediat, Div Pediat Neurol, Chunchon 200702, South Korea;

Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 136703, South Korea;

Korea Univ, Dept Biomed Engn, Seoul 136701, South Korea;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种英语
中图分类普通生物学;
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Central Nervous System and its Disease Models on a Chip

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