Platforms for enrichment of phosphorylated proteins and peptides in proteomics

Iris L Batalha; Christopher R. Lowe; Ana C.A. Roque

首页> 外文期刊>Trends in biotechnology >Platforms for enrichment of phosphorylated proteins and peptides in proteomics

【24h】

Platforms for enrichment of phosphorylated proteins and peptides in proteomics

机译：Platforms for enrichment of phosphorylated proteins and peptides in proteomics

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Protein phosphorylation is a complex and highly dynamic process involved in numerous biological events. Abnormal phosphorylation is one of the underlying mechanisms for the development of cancer and metabolic disorders. The identification and absolute quantification of specific phospho-signatures can help elucidate protein functions in signaling pathways and facilitate the development of new and personalized diagnostic and therapeutic tools. This review presents a variety of strategies currently utilized for the enrichment of phosphorylated proteins and peptides before mass spectrometry analysis during proteomic studies. The investigation of specific affinity reagents, allied to the integration of different enrichment processes, is triggering the development of more selective, rapid and cost-effective high-throughput automated platforms.

著录项

来源
《Trends in biotechnology》 |2012年第2期|100-110|共11页
作者
Iris L Batalha; Christopher R. Lowe; Ana C.A. Roque;
展开▼
作者单位

Institute of Biotechnology, Department of Chennical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, CB2 1QT, Cambridge, UK;

REQUIMTE, Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal;

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种英语
中图分类普通生物学;
关键词

Platforms for enrichment of phosphorylated proteins and peptides in proteomics

摘要

著录项

相关主题

期刊订阅