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首页> 外文期刊>Artificial Organs >A new pulsatile volumetric device with biomorphic valves for the in vitro study of the cardiovascular system.
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A new pulsatile volumetric device with biomorphic valves for the in vitro study of the cardiovascular system.

机译：带有生物形态瓣膜的新型脉动容积设备，用于体外研究心血管系统。

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摘要

A pulsatile mock loop system was designed and tested. This prototype represents a versatile, adjustable, and controllable experimental apparatus for in vitro studies of devices meant to interface with the human circulatory system. The pumping system consisted of a ventricular chamber featuring two biomorphic silicone valves as the inlet and outlet valves. The chamber volume is forced by a piston pump moved by a computer-controlled, low-inertia motor. Fluid dynamic tests with the device were performed to simulate physiological conditions in terms of cardiac output (mean flow of 5 and 6 L/min, with beat rates from 60 to 80 bpm), of rheological properties of the processed fluid, and of systemic circulation impedance. The pulsating actuator performed a good replication of the physiological ventricular behavior and was able to guarantee easy control of the waveform parameters. Experimental pressure and flow tracings reliably simulated the physiological profiles, and no hemolytic subatmospheric pressures were revealed. The performance of the prototype valves was also studied in terms of dynamic and static backflow, effective orifice area, and pressure loss, resulting in their applicability for this device. Mechanical reliability was also tested over 8 h. The device proved to be a reliable lab apparatus for in vitro tests; the pumping system also represents a first step toward a possible future application of pulsating perfusion in the clinic arena, such as in short-term cardiac assist and pulsatile cardiopulmonary bypass.
机译：设计并测试了搏动模拟回路系统。该原型代表了一种多功能，可调节和可控制的实验设备，用于体外研究旨在与人体循环系统对接的设备。泵系统由一个心室腔组成，该心室腔具有两个生物形态硅酮阀作为入口阀和出口阀。腔室的体积由计算机控制的低惯性电机驱动的活塞泵推动。使用该设备进行了流体动力学测试，以模拟生理条件，包括心输出量（平均流量为5和6 L / min，搏动速率为60至80 bpm），加工液的流变性和体循环阻抗。脉动致动器可以很好地复制生理性心室行为，并且能够保证轻松控制波形参数。实验压力和流量示踪可靠地模拟了生理曲线，并且没有发现溶血性低于大气压的压力。还对原型阀的性能进行了动态和静态回流，有效孔面积和压力损失方面的研究，从而确定了它们在该设备中的适用性。机械可靠性也在8小时内进行了测试。该设备被证明是用于体外测试的可靠实验室设备。泵送系统也代表了在临床舞台上可能将来应用脉动灌注的第一步，例如在短期心脏辅助和脉动性体外循环中。

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