AbstractThe excretion of HCH (hexachlorocyclohexane) residues in the milk of Indian buffalo, the main milch cattle of India, after oral or dermal exposure to technical HCH was studied. Following the intake of 10, 25,50 and 100 mg of technical HCH by different groups of buffaloes, HCH residues in milk showed an initial rapid rise but soon attained a dose‐dependent equilibrium. The transfer coefficient of HCH residues in milk fat at 'plateau' showed an average value of about 15%. Half‐life values for the rate of decline of HCH residues during the post‐dosing period were computed according to a two open‐compartment model. Dermal application of technical HCH to buffaloes also resulted in significant residues in milk. The proportions of alpha‐, beta‐, gamma‐ and delta‐isomers of HCH in milk of buffaloes following oral and dermal routes of exposures were different. The significance of these results in the regulation of HCH residues in mi
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