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首页> 外文期刊>Digestive diseases >PIK3R3 Missense and NOTCH2 Synonymous Single Nucleotide Polymorphisms Are Associated with Liver Cancer
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PIK3R3 Missense and NOTCH2 Synonymous Single Nucleotide Polymorphisms Are Associated with Liver Cancer

机译:PIK3R3 Missense and NOTCH2 Synonymous Single Nucleotide Polymorphisms Are Associated with Liver Cancer

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摘要

Background: Single nucleotide polymorphism (SNP) of candidate genes also affects the occurrence and prognosis of liver cancer. We mainly explored the effects of PIK3R3 and NOTCH2 polymorphisms on liver cancer risk among Chinese people. Methods: Four SNPs (rs785468, rs785467, rs3795666, and rs17024525 in PIK3R3 and NOTCH2) from 709 liver cancer patients and 700 healthy controls were genotyped using the Agena MassARRAY system. The correlation between SNPs and liver cancer risk was evaluated using logistic regression analysis. The SNP-SNP interactions were conducted by the multifactor dimensionality reduction method. Results: The results revealed that PIK3R3-rs785467 reduced the likelihood of liver cancer among Chinese Han people (p 55 years, p 55 years (p < 0.05). Conclusions: Our results demonstrate that PIK3R3-rs785476 and NOTCH2-rs3795666 polymorphisms are responsible for decreasing the susceptibility of liver cancer development in the Chinese Han population.

著录项

  • 来源
    《Digestive diseases》 |2023年第3期|458-467|共10页
  • 作者单位

    Department of Radiation Therapy, Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China;

    Department of Oncology, Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China;

    Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi’an, ChinaDepartment of Radiotherapy, Shaanxi Provincial Cancer Hospital Affiliated to Medical College, Xi’anDepartment of Orthopedic, Xi’an Ninth Hospital, Xi’an, ChinaDepartment of Human Anatomy and Tissue Embryology, School of Basic Medical Sciences, Xi’an JiaotongDepartment of Radiology, Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, First Affiliated Hospital, Xi’an Jiaotong University, Xi’an;

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  • 原文格式 PDF
  • 正文语种 英语
  • 中图分类 消化系及腹部疾病;
  • 关键词

    Liver cancer; PIK3R3; NOTCH2; Polymorphism;

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