BPA-Containing Polydopamine Nanoparticles for Boron Neutron Capture Therapy in a U87 Glioma Orthotopic Model

Liqun Dai; Jie Liu; Xiaosheng ZhaoYuhao LiSiming ZhouLiping YuanDiyun ShuLili PanYuan-hao LiuZhiyong Qian

首页> 外文期刊>Advanced functional materials >BPA-Containing Polydopamine Nanoparticles for Boron Neutron Capture Therapy in a U87 Glioma Orthotopic Model

【24h】

BPA-Containing Polydopamine Nanoparticles for Boron Neutron Capture Therapy in a U87 Glioma Orthotopic Model

机译：BPA-Containing Polydopamine Nanoparticles for Boron Neutron Capture Therapy in a U87 Glioma Orthotopic Model

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Boron neutron capture therapy (BNCT) is a promising therapy for refractorycancer based on the cytotoxic reaction of ~(10)B (n, α) ~7Li. Although two BNCTagents are clinically available, they are quickly metabolized and show modestenrichment in tumor sites, partially limiting BNCT widespread application.Consequently, novel agents that perform active targeting and show good biocompatibilityhave to be developed. Herein, boronophenylalanine-containingpolydopamine (B-PDA) nanoparticles are easily fabricated by encapsulatingboronophenylalanine (BPA) in polydopamine via nitrogen-boronate coordination.In this study, B-PDA achieves increased tumor accumulation and prolongedretention effects in the tumor site and superior antitumor activity postneutron irradiation in the orthotopic xenograft glioma model. In brief, thisstudy offers a novel strategy for BPA delivery and may broaden the perspectiveon nanomedicine design for BNCT.

著录项

来源
《Advanced functional materials》 |2023年第23期|2214145.1-2214145.13|共13页
作者
Liqun Dai; Jie Liu; Xiaosheng ZhaoYuhao LiSiming ZhouLiping YuanDiyun ShuLili PanYuan-hao LiuZhiyong Qian;
展开▼
作者单位

State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan UniversityCollaborative Innovation Center of BiotherapyChengdu 610041, China;

Laboratory of Clinical Nuclear MedicineDepartment of Nuclear MedicineWest China Hospital, Sichuan UniversityChengdu 610041, China;

Nanjing University of Aeronautics and AstronauticsNanjing, Jiangsu 210016, China Neuboron Medtech Ltd.Nanjing, Jiangsu 211112, China;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
boron neutron capture therapy; BPA delivery; B-PDA; glioma;

BPA-Containing Polydopamine Nanoparticles for Boron Neutron Capture Therapy in a U87 Glioma Orthotopic Model

摘要

著录项

相关主题

期刊订阅