Novel 6-methoxycarbonyl indolinones bearing a pyrrole Mannich base moiety as angiokinase inhibitors

Qin Mingze; Yan Shuang; Wang LeiZhang HaotianTian YeZhao YanfangGong Ping

首页> 外文期刊>Bioorganic and medicinal chemistry >Novel 6-methoxycarbonyl indolinones bearing a pyrrole Mannich base moiety as angiokinase inhibitors

【24h】

Novel 6-methoxycarbonyl indolinones bearing a pyrrole Mannich base moiety as angiokinase inhibitors

机译：Novel 6-methoxycarbonyl indolinones bearing a pyrrole Mannich base moiety as angiokinase inhibitors

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Inhibition of tumor angiogenesis through simultaneously disturbing vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) mediated signaling pathways is a well-established approach in intervention of tumor. A series of 6-methoxycarbonyl indolinones bearing a pyrrole Mannich base moiety were synthesized and evaluated as potent angiokinase inhibitors. Compound 8a demonstrated favorable enzymatic activity against all subtypes of VEGFR and PDGFR. Also, it potently suppressed proliferation of HT-29 cells by inducing apoptosis. Compound 8a has emerged as a promising lead compound for development of angiokinase inhibitors targeting VEGFR and PDGFR. (C) 2017 Elsevier Ltd. All rights reserved.

著录项

来源
《Bioorganic and medicinal chemistry》 |2017年第6期|1778-1786|共9页
作者
Qin Mingze; Yan Shuang; Wang LeiZhang HaotianTian YeZhao YanfangGong Ping;
展开▼
作者单位

Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, 103 Wenhua Rd;

Shenyang Pharmaceut Univ, Dept Pharmacol, 103 Wenhua Rd, Shenyang 110016, Peoples R China;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类药学;
关键词
6-Methoxycarbonyl indolinones; Conformational restriction strategy; Angiokinase inhibitors; Antitumor activity;

Novel 6-methoxycarbonyl indolinones bearing a pyrrole Mannich base moiety as angiokinase inhibitors

摘要

著录项

相关主题

期刊订阅