Surface modified lanthanide upconversion nanoparticles for drug delivery, cellular uptake mechanism, and current challenges in NIR-driven therapies

Ansari Anees A. A.; Parchur Abdul K. K.; Chen Guanying

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Surface modified lanthanide upconversion nanoparticles for drug delivery, cellular uptake mechanism, and current challenges in NIR-driven therapies

机译：Surface modified lanthanide upconversion nanoparticles for drug delivery, cellular uptake mechanism, and current challenges in NIR-driven therapies

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Lanthanides(Ln(3+)) are a particular class of optical materials and are regularly utilized as a structure block for architectures of optoelectronic frameworks because of their excellent emission properties extending from ultraviolet(UV)/Visible to near-infrared (NIR) region. Upconversion nanoparticles (UCNPs) uncovered noteworthy qualities, like the least to-harmfulness, fantastic biocompatibility, excellent colloidal dispersibility, and limited photograph harm, auto-fluorescence free, high thermal, mechanical, and photochemical robustness contrasted with other luminescent NPs. Therefore, UCNPs offer attractive opportunities in nanomedicine to fight against cancerous diseases. Recently, the NIR light irradiation takes into deliberation to enhanced infiltration insight and successful applications in cancer diagnostics and cure because NIR light produces minimum side effects on biological cells/tissues during cancer treatment. In this review, we emphasize the various issues, which are important in theranostics/ drug delivery appli-cations. Surface functionalization to improve the biocompatibility, toxic potentiality, and enhanced the drug loading over the surface of luminescent NPs. The review discussed the mechanism of UCNPs inter-action with cells/tissues. The interaction of UCNPs with cells/tissues changed the bio-distribution pro-cess, chemically responsive crossing point, and the fusion of solid-state properties and chemical kinetics of the molecules. Moreover, this review discussed the modern development of NIR light-responsive theranostic applications through various techniques such as photodynamic therapy (PDT), photothermal therapy (PTT), chemotherapy, and drug delivery applications. Specifically, the UCNPs will give an ideal multifunctional forum to answers for some center clinical science issues, for example, theranostics, personalized treatment, multimodality medication, and so on. The most successful protocols are implemented in-depth. To include a general overview and recommend future study directions, existing shortcomings, and future opportunities are also included. (C) 2022 Elsevier B.V. All rights reserved.

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《Coordination chemistry reviews》 |2022年第4期|214423.1-214423.34|共34页
作者
Ansari Anees A. A.; Parchur Abdul K. K.; Chen Guanying;
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作者单位

King Saud Univ, King Abdullah Inst Nanotechnol, Riyadh 11451, Saudi Arabia;

Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA;

Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150010, Peoples R China|Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150010, Peoples R China;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种英语
中图分类
关键词
Luminescent; Lanthanides; Upconversion; Functionalization; Theranostics;

Surface modified lanthanide upconversion nanoparticles for drug delivery, cellular uptake mechanism, and current challenges in NIR-driven therapies

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