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>LACK OF ALTERATION IN CARDIAC beta;hyphen;ADRENOCEPTOR SITE CONCENTRATION IN RATS TREATED WITH AN ADENYLATE CYCLASEhyphen;STIMULATING DOSE OF ENDOTOXIN
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LACK OF ALTERATION IN CARDIAC beta;hyphen;ADRENOCEPTOR SITE CONCENTRATION IN RATS TREATED WITH AN ADENYLATE CYCLASEhyphen;STIMULATING DOSE OF ENDOTOXIN
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机译：LACK OF ALTERATION IN CARDIAC beta;hyphen;ADRENOCEPTOR SITE CONCENTRATION IN RATS TREATED WITH AN ADENYLATE CYCLASEhyphen;STIMULATING DOSE OF ENDOTOXIN
In previous experiments on male rats we showed that 2 mg kg-1, intravenously, lipopolysaccharide fromEscherichia coli, a sublethal nonhypotensive dose, induced circulating cardiodepressant activity, maximal alterations in steroid hormonal response, and myocardial adenylate cyclase hyperactivity 4 h later. The purpose of the present study was to investigate a possible relation between this adenylate cyclase hyperactivity and alterations in total ventricular β-adrenoceptors. To this end, ventricular β-adrenoceptor concentration and affinity were measured under the same conditions. Binding assays were performed using [3H]dihydroalprenolol. No significant change was observed in both parameters.
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