SummaryFour different C57BL/6 mutants, each with a mutation presumably in the H‐2Kblocus, were studied to determine whether the mutations had affectedIrgene function. When tested with the antigens, (TG)‐A‐L, ovalbumin (OA), and lactic dehydrogenase (LDH8), there was no difference in the antibody response of the mutants when compared to the parental C57BL/6 strain and there was also no difference in the response to the histocompatibility H‐Y antigen. The responses to these antigens have been mapped, wholly or partially in the K‐IA, IA or IB subregions and therefore the identical response of parent and mutants may provisionally exclude H‐2Kbas a site ofIrgene function for the four antigens tested. In addition, the BALB/c‐dm2mutant, a mutation in the H‐2Ldlocus, gave identical responses to the parental
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