Lung and lymph node metastases from hepatocellular carcinoma: Comparison of pathological aspects

Ha Young Woo; Hyungjin Rhee; Jeong Eun YooSe Hoon KimGi Hong ChoiDo Young KimHyun Goo WooHye Sun LeeYoung Nyun Park

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Lung and lymph node metastases from hepatocellular carcinoma: Comparison of pathological aspects

机译：Lung and lymph node metastases from hepatocellular carcinoma: Comparison of pathological aspects

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Abstract Background & Aims Extrahepatic metastasis from hepatocellular carcinoma (HCC) is a catastrophic event, yet organ‐specific pathological characteristics of metastatic HCC remain unclear. We aimed to characterize the pathological aspects of HCC metastases to various organs. Methods We collected intrahepatic HCC (cohort 1, n?=?322) and extrahepatic metastatic HCC (cohort 2, n?=?130) samples. Clinicopathological evaluation and immunostaining for K19, CD34, αSMA, fibroblast‐associated protein (FAP), CAIX, VEGF, PD‐L1, CD3, CD8, Foxp3, CD163 and epithelial–mesenchymal transition (EMT)‐related markers were performed. Results Independent factors for extrahepatic metastasis included BCLC stage B–C, microvascular invasion (MVI), vessels encapsulating tumour clusters (VETC)‐HCC, K19 and FAP expression, and CD163+ macrophage infiltration (cohort 1, P?

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《Liver international》 |2022年第1期|199-209|共11页
作者
Ha Young Woo; Hyungjin Rhee; Jeong Eun YooSe Hoon KimGi Hong ChoiDo Young KimHyun Goo WooHye Sun LeeYoung Nyun Park;
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Department of Pathology,Yonsei University College of Medicine;

Department of Radiology,Yonsei University College of Medicine;

Department of Surgery,Yonsei University College of MedicineDepartment of Internal Medicine,Yonsei University College of MedicineDepartment of Physiology,Ajou University School of MedicineBiostatistics Collaboration Unit,Yonsei University College of Medicine;

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正文语种英语
中图分类内科学;
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epithelial–mesenchymal transition; extrahepatic metastasis; hepatocellular carcinoma; keratin 19; macrotrabecular‐massive; vessels encapsulating tumour clusters;

Lung and lymph node metastases from hepatocellular carcinoma: Comparison of pathological aspects

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