Synthesis of Novel Pyrazolines, Their Boron-Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities

Kahriman Nuran; Hasimoglu Zeynep; Serdaroglu VildanBeris Fatih SabanBarut BurakYayli Nurettin

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Synthesis of Novel Pyrazolines, Their Boron-Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities

机译：新型吡唑啉及其硼氟络合物的合成，以及抗菌、抗氧化和酶抑制活性的研究

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3,5-disubstituted-2-pyrazoline derivatives (4-6), their boron-fluorine complexes (boron (3-(2'-aminophenyl), 5-(2'-/3'-/4'-pyridyl) pyrazoline, BOAPPY) (7-9) and boron 1,2'-diazaflavone complex (BODAF) (11) were synthesized starting from azachalcones (1-3) to diazaflavone (10), respectively. Biological evaluation of compounds 4-9 and 11 showed remarkable antioxidant, antibacterial, and acetylcholinesterase and tyrosinase enzyme inhibition activities. All newly synthesized compounds 4-9 and 11 showed respectable antibacterial effect with minimum inhibitory concentrations in the range of 4.7-150mg/mL.

机译：从氮杂沙尔酮（1-3）到二氮杂黄酮（10）分别合成了3,5-二取代-2-吡唑啉衍生物（4-6）及其硼氟配合物（硼（3-（2'-氨基苯基）、5-（2'-/3'-/4'-吡啶基）吡唑啉、BOAPPY）（7-9）和硼1,2'-二氮杂黄酮络合物（BODAF）（11）。化合物 4-9 和 11 的生物学评价显示出显着的抗氧化、抗菌、乙酰胆碱酯酶和酪氨酸酶抑制活性。所有新合成的化合物4-9和11均表现出可观的抑菌效果，最低抑菌浓度在4.7-150mg/mL范围内。

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《Archiv der Pharmazie》 |2017年第2期|e1600285-e1600285|共12页
作者
Kahriman Nuran; Hasimoglu Zeynep; Serdaroglu VildanBeris Fatih SabanBarut BurakYayli Nurettin;
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作者单位

Karadeniz Tech Univ, Dept Chem, Fac Sci, TR-61080 Trabzon, Turkey;

Recep Tayyip Erdogan Univ, Dept Biol, Fac Arts & Sci, Rize, Turkey;

Karadeniz Tech Univ, Dept Biochem, Fac Pharm, Trabzon, Turkey;

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正文语种德语
中图分类药学;
关键词
Azachalcone; Azaflavone; BOAPPY; BODAF; Pyrazoline;

机译：氮杂查尔酮;氮杂黄酮;BOAPPY;博达夫;吡唑啉;

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Synthesis of Novel Pyrazolines, Their Boron-Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities

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