AbstractThe metabolism of propetamphos by insecticide‐resistant and susceptible houseflies,in vivo, was investigated. Two major pathways of propetamphos degradation were found. The first is the major route of detoxification for both resistant and susceptible strains at low doses and involves a hydrolysis of theP–O‐vinyl bond, ultimately resulting in the formation of carbon dioxide. The second major pathway involves conjugation. As the dose increases, so does the importance of this pathway. Those strains of houseflies with greater conjugative capacity are able to tolerate greater doses of propetamphos than those strains with lesser conjugative capacity. The properties exhibited by this conjugate are consistent with those of glutathione conjugates. This is further supported by a parallel between reported values of glutathioneS‐transferase activity in the houseflies tested and tolerance to prope
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