Liquid Contact Ion Selective Electrode Green Method for the Determination of Flavoxate HCl Main Active Metabolite in Pure Powder and Human Urine with Establishment of Urinary Excretion Pattern

Mona T. Ragab; Nesrin K. Ramadan; Nariman A. El‐RagehyBadr A. El‐Zeany

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Liquid Contact Ion Selective Electrode Green Method for the Determination of Flavoxate HCl Main Active Metabolite in Pure Powder and Human Urine with Establishment of Urinary Excretion Pattern

机译：Liquid Contact Ion Selective Electrode Green Method for the Determination of Flavoxate HCl Main Active Metabolite in Pure Powder and Human Urine with Establishment of Urinary Excretion Pattern

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Abstract The main aim of this work is to develop the first liquid contact ion selective electrode potentiometric method for determination of flavoxate HCl main metabolite; 3‐methylflavone‐8‐carboxylic acid (MFC). The method can be used for studying flavoxate HCl bioavailability through tracing its active metabolite; MFC, excreted in human urine. The metabolite was determined in pure powder and in human urine with establishment of urinary excretion pattern without any sample extraction or pretreatment procedures. The suggested sensor‘s performance was assessed in accordance with IUPAC guidelines. According to the Bioanalytical Method Validation Guidance for Industry, the suggested method was validated where good results were obtained. The proposed method is an excellent green eco‐friendly analytical method.

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来源
《Electroanalysis》 |2022年第11期|1690-1700|共11页
作者
Mona T. Ragab; Nesrin K. Ramadan; Nariman A. El‐RagehyBadr A. El‐Zeany;
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作者单位

Cairo University;

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原文格式 PDF
正文语种英语
中图分类电化学、电解、磁化学;
关键词
Bioanalytical Method Validation; Flavoxate HCl; Ion Selective Electrodes; 3-Methylflavone-8-Carboxylic Acid; Urinary excretion pattern;

Liquid Contact Ion Selective Electrode Green Method for the Determination of Flavoxate HCl Main Active Metabolite in Pure Powder and Human Urine with Establishment of Urinary Excretion Pattern

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