A nanodrug incorporating siRNA PD-L1 and Birinapant for enhancing tumor immunotherapy

Gong Tingting; Cai Yujun; Sun FengzeChen JiaxinSu ZhongzhenShuai XintaoShan Hong

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A nanodrug incorporating siRNA PD-L1 and Birinapant for enhancing tumor immunotherapy

机译：A nanodrug incorporating siRNA PD-L1 and Birinapant for enhancing tumor immunotherapy

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Triple-negative breast cancer (TNBC) is associated with a worse prognosis and higher mortality than other breast cancers, and intensive effort has been made to develop therapies targeting TNBC. TNBC shows higher expression levels of programmed cell death ligand 1 (PD-L1) than other breast cancer types, which leads to a decrease in the killing effects of CD8(+) T cells in the tumor microenvironment. Inhibitors of apoptosis proteins (IAPs) could prevent cell death through suppressing caspase activity. Here, Birinapant, an antagonist of IAPs, was found to promote the tumor infiltration of CD8(+) T cells via increasing the secretion of the chemokine CXCL9. In addition, Birinapant could inhibit tumor growth via increasing the secretion of and the sensitivity to TNF-alpha in a TNBC xenotransplantation mouse model. Consequently, liposomes encapsulating Birinapant and siPD-L1 mediated a form of combination therapy based on two drugs to significantly increase the therapeutic effects toward TNBC.

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《Biomaterials Science》 |2021年第23期|8007-8018|共12页
作者
Gong Tingting; Cai Yujun; Sun FengzeChen JiaxinSu ZhongzhenShuai XintaoShan Hong;
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作者单位

Sun Yat Sen Univ, Affiliated Hosp 5, Dept Ultrasound, Zhuhai 519000, Peoples R China;

Sun Yat Sen Univ, Sch Mat Sci & Engn, PCFM Lab, Minist Educ, Guangzhou 510275, Peoples R China;

Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Dept Biotherapy, State Key Lab Oncol Southern China, Guangzhou 510000, Peoples R ChinaSun Yat Sen Univ, Guangdong Prov Key Lab Biomed Imaging, Affiliated Hosp 5, Zhuhai, Peoples R China;

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正文语种英语
中图分类分子生物学;
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A nanodrug incorporating siRNA PD-L1 and Birinapant for enhancing tumor immunotherapy

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