Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection

Schaapman Jelte J.; Amoros àlex; Reijden Johan J.Laleman WimZeuzem StefanBa?ares RafaelJalan RajivArroyo VicenteClària JoanVerspaget Hein W.Coenraad Minneke J.

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Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection

机译：Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection

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Abstract Background & Aims Acute‐on‐chronic liver failure (ACLF) is characterized by acute decompensation of cirrhosis (AD), organ failure(s) and high risk of short‐term mortality with bacterial infection frequently as precipitating event. Innate immune pattern recognition receptors and members of the lectin pathway of complement activation are crucial to the innate immune response to pathogens. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) of innate immune components are associated with the occurrence of bacterial infections or mortality in patients with cirrhosis hospitalized for AD or ACLF. Methods Twenty‐one innate immunity SNPs with known functional implications were genotyped in 826 AD/ACLF patients included in the CANONIC study. Associations between baseline characteristics of the patients, the occurrence of bacterial infections and survival rate at 90?days of follow‐up in relation to the innate immunity genetic variants were analysed. Results The NOD2‐G908R genetic variant was associated with mortality (HR 2.25, P ?=?.004) independently of age and MELD Score. This association was also found in a predefined subgroup analysis in patients with bacterial infections (HR 2.78, P ??.001) along with MBL_Yx (HR 1.72, P ?=?.008) and MASP2_371 (HR 1.67, P ?=?.012) genetic variants. None of the analysed SNPs were significantly associated with the occurrence of acute bacterial infections or spontaneous bacterial peritonitis in particular. Conclusions Innate immune system‐specific NOD2‐G908R, MBL_Yx and MASP2_371 genetic variants were independently associated with increased risk of short‐term mortality in AD/ACLF patients with bacterial infection.

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《Liver international》 |2020年第3期|646-653|共8页
作者
Schaapman Jelte J.; Amoros àlex; Reijden Johan J.Laleman WimZeuzem StefanBa?ares RafaelJalan RajivArroyo VicenteClària JoanVerspaget Hein W.Coenraad Minneke J.;
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Leiden University Medical CenterLeiden,The Netherlands;

European Foundation for the study of Chronic Liver FailureBarcelona,Spain;

UZ LeuvenLeuven,BelgiumUniversit?tsklinikum FrankfurtFrankfurt am Main,GermanyGregorio Mara?ón HospitalMadrid,SpainUniversity College LondonLondon,UK;

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正文语种英语
中图分类内科学;
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acute‐on‐chronic liver failure; bacterial infection; end‐stage liver disease; innate immunity; single nucleotide polymorphism;

Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection

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