Effects of low-frequency repetitive transcranial magnetic stimulation in adductor laryngeal dystonia: a safety, feasibility, and pilot study

Cecília N.Prudente; MoChen; Kaila L.StipancicKatherine L.MarksSharylSamargia-GrivetteGeorge S.GodingJordan R.GreenTeresa J.Kimberley

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Effects of low-frequency repetitive transcranial magnetic stimulation in adductor laryngeal dystonia: a safety, feasibility, and pilot study

机译：Effects of low-frequency repetitive transcranial magnetic stimulation in adductor laryngeal dystonia: a safety, feasibility, and pilot study

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Abstract Purpose The effects of neuromodulation are virtually unexplored in adductor laryngeal dystonia (AdLD), a disorder characterized by involuntary contraction of intrinsic laryngeal muscles. Recent findings indicated that intracortical inhibition is reduced in people with AdLD. Low-frequency repetitive transcranial magnetic stimulation (rTMS) induces prolonged intracortical inhibition, but the effects in AdLD are unexplored. This pilot and feasibility study aimed to examine the safety, feasibility, and effects of a single session 1?Hz rTMS over the laryngeal motor cortex (LMC) in people with AdLD and healthy individuals.Methods The stimulation location was individualized and determined through TMS-evoked responses in the thyroarytenoid muscles using fine-wire electrodes. 1200 pulses of 1?Hz rTMS were delivered to the left LMC in two groups: Control (n?=?6) and AdLD (n?=?7). Tolerance, adverse effects, intracortical inhibition, and voice recordings were collected immediately before and after rTMS. Voice quality was assessed with acoustic-based and auditory-perceptual measures.Results All participants tolerated the procedures, with no unexpected adverse events or worsening of symptoms. No significant effects on intracortical inhibition were observed. In the AdLD group, there was a large-effect size after rTMS in vocal perturbation measures and a small-effect size in decreased phonatory breaks.Conclusions One rTMS session over the LMC is safe and feasible, and demonstrated trends of beneficial effects on voice quality and phonatory function in AdLD. These preliminary findings support further investigation to assess clinical benefits in a future randomized sham-controlled trial.ClinicalTrials.gov NCT02957942, registered on November 8, 2016.

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《Experimental Brain Research》 |2022年第2期|561-574|共14页
作者
Cecília N.Prudente; MoChen; Kaila L.StipancicKatherine L.MarksSharylSamargia-GrivetteGeorge S.GodingJordan R.GreenTeresa J.Kimberley;
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作者单位

Divisions of Physical Therapy and Rehabilitation Science, Department of Rehabilitation Medicine;

Non-Invasive Neuromodulation Laboratory, MnDRIVE Initiative,University of Minnesota;

Department of Communication Sciences and Disorders, School of Health and Rehabilitation SciencesDepartment of Communication Sciences and Disorders,University of Minnesota-DuluthDepartment of Otolaryngology-Head and Neck Surgery,University of Minnesota;

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正文语种英语
中图分类神经病学;
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Adductor laryngeal dystonia; Spasmodic dysphonia; Repetitive transcranial magnetic stimulation; Cortical silent period; Acoustics;

Effects of low-frequency repetitive transcranial magnetic stimulation in adductor laryngeal dystonia: a safety, feasibility, and pilot study

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