SPIKE GLYCOPROTEIN OF CORONAVIRUS OF ANIMALS AND SARS-COV-2

Bramhadev Pattnaik; Kuralayanapalya Puttahonnappa Suresh; Chandan ShivamalluShiva Prasad KollurMahendra P. YadavSiju Susan JacobAwadh B. PandeyKirankere Ananthapadmanabha ShyamsundarSharanagouda S. Patil

首页> 外文期刊>Indian journal of comparative microbiology, immunology and infectious dieases >SPIKE GLYCOPROTEIN OF CORONAVIRUS OF ANIMALS AND SARS-COV-2

【24h】

SPIKE GLYCOPROTEIN OF CORONAVIRUS OF ANIMALS AND SARS-COV-2

机译：SPIKE GLYCOPROTEIN OF CORONAVIRUS OF ANIMALS AND SARS-COV-2

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Family Coronaviridae comprises genetically and antigenieally diverse (both inter- and intra-genotypic) virus populations that infect vertebrates including man, animals and poultry. The coronaviruses (CoVs) have large projections (peplomers/ spikes) of about 20nm on the envelope that forms solar corona-like features on the virion, first identified in avian Infectious bronchitis virus (IBV) in 1930s. This followed identification of Mouse Hepatitis Virus (MHV) and porcine Transmissible Gastroenteritis Virus (TGEV), and human CoVs in 1940s and 1960s, respectively. Identification of the Severe Acute Respiratory Syndrome (SARS) agent of 2003 as a CoV was facilitated by visualization of virion surface projections of >20nm in electron microscopy. The virus structure is composed of 4 structural proteins, Spike (180-200kDa; orf2), Envelope (8-10kDa; orf3), Membrane (20-30kDa; orf4) and Nucleoprotein (50-60kDa; orf5). The viral genome also codes for non-structural proteins (up to 16 in SARS-CoV-2) in orfl (pplab), and accessory proteins (up to 9 in SARS-CoV-2) encoded by orfs interspersed between the four structural protein genes/orfs. Different species of CoV primarily vary in the size of ORF2 that codes for the Spike (S) glycoprotein. There are 13 different CoV species prevalent in humans (7) and porcine (6). Determinants of antigenic diversity are primarily located in the Spike (S) glycoprotein/ gene. The spike is composed of S protein trimers that bind to host cell receptor (one spike trimer can bind to 3 molecules of host receptor) to initiate virus infection cycle, determines host/ cell tropism, susceptibility, transmissibility, and pathogenicity. Most of the information on S gene and the S glycoprotein and their diversity are generated in IBV and MHV models, and of late in SARS-CoV-2. Spike protein differs in conformation among CoV species, that is whether the S protein cleaved or not during virion morphogenesis. In gamma-CoVs and a few beta-CoV, the S protein is cleave

著录项

来源
《Indian journal of comparative microbiology, immunology and infectious dieases》 |2022年第2期|154-176|共23页
作者
Bramhadev Pattnaik; Kuralayanapalya Puttahonnappa Suresh; Chandan ShivamalluShiva Prasad KollurMahendra P. YadavSiju Susan JacobAwadh B. PandeyKirankere Ananthapadmanabha ShyamsundarSharanagouda S. Patil;
展开▼
作者单位

Institute of Veterinary Sciences and Animal Husbandry, SOA University, Odisha, India &Former Director, ICAR-DFMD, Mukteswar, Nainital, India and FAO Ref Centre for FMD in South Asia, Bhubaneswar, Odisha, India;

ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, Karnataka, India;

Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education &Research, Mysuru, Karnataka, IndiaDepartment of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapcetham, Mysuru Campus,Mysuru, Karnataka, IndiaFormer Vice Chancellor, Sardar Vallabhbhai Patel University of Agriculture &Technology, Mecrut, Uttar Pradesh, IndiaFormer Principal Scientist, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, IndiaDepartment of Veterinary Microbiology, Veterinary College (KVAFSU), Hebbal, Bangalore Karnataka, India;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类微生物学;
关键词
BCoV; CCoV; Coronavirus; FIPV; IBV; SARS-CoV-2; Spike gene; Spike glycoprotein; TGEV;

SPIKE GLYCOPROTEIN OF CORONAVIRUS OF ANIMALS AND SARS-COV-2

摘要

著录项

相关主题

期刊订阅