AbstractSodium salicylate significantly inhibits the ability of saline extracts of human articular cartilage to decrease the viscosity of chondromucoprotein. Two groups of rabbits were subjected to superficial scarification of their knee articular cartilage. Those rabbits receiving sodium salicylate in their diets did not develop many of the degenerative changes seen in the untreated animals. Salicylate inhibition of chondromucoprotein degradation in vitro and cartilage degeneration in vivo has been shown for the first time.
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