AbstractThe effect of recombinant human interleukin‐6 (rhlL‐6) on induction of nitrite (NO 2−) production was investigated in a mouse myeloid leukemia cell line (M1) and a subclone (Mm1). NO 2−was induced by rhlL‐6 (>50 U/ml) in these cell lines. Pretreatment with rhlL‐6 (100 U/ml) for 1 day synergistically enhanced the production of NO 2−in Mm1 by LPS. Furthermore, pretreatment withl lL‐6 (100 U/ml) shortened the lag time of induction. These results indicate that lL‐6 is involved in the regulation of the NO 2−producti
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