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首页> 外文期刊>Infectious disorders drug targets >The Anti-infective Potential of Hydroalcoholic Extract of Phyllanthus emblica Seeds Against Selected Human-pathogenic Bacteria Bentham Science
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The Anti-infective Potential of Hydroalcoholic Extract of Phyllanthus emblica Seeds Against Selected Human-pathogenic Bacteria Bentham Science

机译：The Anti-infective Potential of Hydroalcoholic Extract of Phyllanthus emblica Seeds Against Selected Human-pathogenic Bacteria Bentham Science

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Introduction: In the context of the global threat of antimicrobial resistance (AMR)among bacterial pathogens against conventional bactericidal antibiotics, investigation on complementary/alternative approaches to manage bacterial infections is warranted. The present studyaimed at investigating the anti-pathogenic potential of Phyllanthus emblica seed extract (PESE)against four different pathogenic bacteria.Methods: Hydroalcoholic extract of P. emblica seeds was tested for its possible in vitro quorummodulatorypotential against Chromobacterium violaceum, Serratia marcescens, Pseudomonasaeruginosa, and Staphylococcus aureus through broth dilution assay. In vivo efficacy of PESEwas assayed employing Caenorhabditis elegans as the model host for these four pathogens.Results: PESE was found to exert in vitro quorum-modulatory effect on C. violaceum, S. marcescens,P. aeruginosa, and S. aureus at ≥50 μg/mL. This extract could curb the haemolytic activityof all the four test bacteria by 23-65%, inhibit biofilm formation, and was also able to modulatetheir antibiotic susceptibility (AS) and catalase activity. Susceptibility of P. aeruginosa and S.aureus to lysis by human serum was enhanced under the influence of this extract by 23% and49%, respectively. Repeated exposure of both these notorious pathogens to PESE did not induceresistance in them. In vivo assay confirmed the anti-virulence effect of this extract in the C. eleganshost, wherein the nematode host challenged with the PESE-treated pathogenic bacteriascored better survival. PESE also displayed notable prebiotic potential by promoting the growth ofthree probiotic strains.Conclusion: To the best of our awareness, this is the first report on the quorum-modulatory potentialof P. emblica seed extract, validating its anti-infective potential and prebiotic property.

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