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首页> 外文期刊>Infectious disorders drug targets >Molecular Analysis of Pseudomonas aeruginosa Metallo-Beta-Lactamase: A First Report of an Iranian Referral Pediatric Hospital
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Molecular Analysis of Pseudomonas aeruginosa Metallo-Beta-Lactamase: A First Report of an Iranian Referral Pediatric Hospital

机译：Molecular Analysis of Pseudomonas aeruginosa Metallo-Beta-Lactamase: A First Report of an Iranian Referral Pediatric Hospital

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Introduction: Pseudomonas aerouginosa is an important opportunisticpathogen which causes clinical infections among ill patients. Metallo- Beta- lactamases(MBLs) are important mechanisms of carbapenem (drug of choice) resistanceamong Pseudomonas aerouginosa isolates. The aim of this study was to determineB- lactamases genes (bla-genes) in P. aerouginosa isolates and to detect percentageof MBLs among P. aerouginosa isolates in different wards.Material and Methods: Clinical isolates of P. aerouginosa in patients hospitalized atChildren's Medical Center were collected in two years using a sterile swab. For differentiationand identification of strains the BHI media, Sytrymaid agar and Oxidasetest were used and Kirby Baure method antibiotic susceptibility and PCR assay wereperformed for detection of bla-genes.Results: Based on the study results from a total of 269 isolates of P. aerouginosa, 39isolates were found to be imipenem resistant. From these isolates, 19 strains of P.aerouginosa isolates were determined to be MBL producers by phenotypic method.All of the Imipenem resistant P. aerouginosa isolates were examined by PCR for thepresence of the bla-genes. All MBL- producing isolates carried bla-IMP Genes. Andthe results of the antibiogram showed the greatest resistance to the Nitrofurantoin,Nalidixic acid and Cotrimoxazole and Cefixime (100%) and resistance to other antibioticswas also significant.Conclusion: Considering the prevalence and clinical importance of MBL producingisolates, rapid identification of them and use of the appropriate infection controlmeasures are necessary to prevent further spread of them by these organisms and tohelp treatment of Infections.

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